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A man 34-years of age had symptoms of bronchopulmonary disease, cough and fever which were controlled by penicillin. The X-ray examination of the chest showed a cavity in the left lung. The examination of the sputum for tubercle bacilli was negative. Two months later the patient re-entered the hospital, complaining of loss of weight.
The bronchopulmonary symptoms had become worse. He also had general cutaneous hypersensitivity and, for the preceding four days, constant bad headaches and left hemiparesis. The cerebrospinal fluid was normal. Within four days meningitis developed. The patient died in coma. An isolated small abscess of the upper lobe of the left lung and an isolated abscess of the right cerebral hemisphere were found at necropsy.
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Within four days _______.